Beschreibung
Indications Premarin preparation:
Replacement therapy in peri – and postmenopausal women, ovarian hypofunction (primary and secondary amenorrhea, oligomenorrhea, dysmenorrhea), sexual infantilism, hypogonadism, secondary estrogen deficiency (including after ovarianctomy for the non-malignant diseases or after radiation castration), breast cancer (somewhat inoperable), androgen-dependent carcinoma of the prostate.
Menopausal syndrome ( „flushes“ of blood in the skin of the upper half, sweat torso, sleep disorders, irritability, depression, vaginitis, urethritis atrophic), postmenopausal osteoporosis, for the prevention of atherosclerosis and CVD in menopause.
Dosage and application:
Inside, the average dose of Premarin for cyclic use is – 0.625 to 1.25 mg / day for 21 days, with an interval of 7 days for all indications except certain cases of breast cancer, prostate and prevention of lactostasis. With continuous treatment is taken every day, for 1 entry.
In the presence of menstrual bleeding treatment, Premarin begins with 5 days of the menstrual cycle, and from 15 to 21 days additionally prescribe a progestin drug. With prolonged absence of menstruation, treatment begins every day. If necessary, for 5-7 days of treatment, the daily dose can be increased to 3.75 mg, then it has been reduced to 1.25 mg.
When intermenstrual bleeding during therapy increases the last dose of estrogen. In the next cycle of the prescribed dose of Premarin, which is needed to stop bleeding in the previous cycle. In the following cycles, the estrogen dose is gradually reduced to maintenance.
When menopausal syndrome determine daily cycles of 1.25 mg of the drug. Increase or decrease the dose, depending on the severity of the symptoms and the patient’s reaction.
