Beschreibung
Description of the active substances „Furosemide“ preparation
pharmacological effects
„Loop“ diuretics. Punishes reabsorption of sodium ions, chlorine in the thick ascending part of the Henle loop segments. Due to the increase in the allocation of sodium ions, secondary (indirect osmotically bound water) increased water excretion and an increase in the secretion of potassium ions in the distal renal tubule occur. At the same time, the excretion of calcium and magnesium ions increases.
It has side effects due to the release of neurotransmitters and intrarenal redistribution of intrarenal blood flow. Against the background of treatment, there is no debilitating effect.
In heart failure quickly leads to a reduction in pretension on the heart dilated by the large veins. It has a hypotensive effect due to the increase and decrease in the chlorine removal reaction of sodium in vascular smooth muscle and vasoconstrictor effects that reduce by the BCC. The effect of furosemide after / in the introduction occurs within 5-10 minutes; after ingestion – 30-60 min, high action – after 1-2 hours, the duration of action – 2-3 hours (with impaired renal function, – up to 8 hours). During the period of excretion of sodium ions significantly increased, but after its completion elimination rate decreases below the reference level (syndrome „rebound“ or „deletion“). The phenomenon is caused by a strong activation of renin-angiotensin and other antinatriuretic neurohormonal control units in response to massive diuresis; Arginine stimulates vazopressive nuyu and the sympathetic system. It reduces the level of atrial antriuretic factor in plasma, resulting in vasoconstriction.
Due to the phenomenon of „bounce“ when receiving once a day can not have a significant influence on the daily excretion of sodium ions and AD. The dilation of the peripheral veins caused on / in the introduction reduces the preload of the left ventricle filling pressure and the pressure in the pulmonary artery, and the systemic blood pressure.
Diuretic effect develops within 3-4 min after i / v injection and lasts 1-2 hours; after oral administration – after 20-30 minutes, continued until 4 hours.
Testimony
of edematous syndrome of various genesis, including chronic heart failure II-III stage of cirrhosis (portal hypertension syndrome), nephrotic syndrome. Pulmonary edema, cardiac asthma, cerebral edema, eclampsia, the performance of compulsion diuresis, hypertension severe, some forms of hypertensive crisis, hypercalcemia.
