Azab 500


Artikelnummer: 678 Kategorien: , Schlüsselwort:


The pharmacological effect of antibiotics macrolides is a representative of azalide. Inhibits RNA-dependent protein synthesis of sensitive microorganisms. It is effective against gram-positive bacteria: Staphylococcus aureus, Streptococcus spp. (Including Streptococcus pneumoniae, Streptococcus pyogenes / group A /); Gram-negative bacteria: Haemophilus influenzae, Haemophilus parainfluenzae, Haemophilus ducreyi, Moraxella catarrhalis, Escherichia coli, Bordetella pertussis, Bordetella parapertussis, Borrelia burgdorferi, Neisseria gonorrhoeae, Campylobacter spp, Legionella pneumophila ;. anaerobic bacteria: Bacteroides fragilis. Azithromycin is also active against Chlamydia trachomatis, Mycoplasma pneumoniae, Mycoplasma hominis, Treponema pallidum. Active also against Toxoplasma gondii. Quickly absorbed from the gastrointestinal tract. Food intake reduces the absorption of azithromycin. CMax in plasma is achieved within 2-3 hours. Quickly distributed in tissues and body fluids. 35% of azithromycin is metabolized in the liver by demethylation. More than 59% was excreted in bile as unchanged, about 4.5% – in the urine in unchanged form. Side effects From the digestive system: nausea, vomiting, flatulence, diarrhea, abdominal pain, temporary increase in liver enzymes; rarely – cholestatic jaundice. Allergic reactions: rarely – rashes, angioedema, erythema multiforme, Stevens-Johnson syndrome, toxic epidermal necrolysis. Dermatological reactions: rarely – sensitivity to light. Co CNS: dizziness, headache; rarely – drowsiness, weakness. From hemopoiesis system: rarely – a leukopenia, neutropenia, thrombocytopenia. Cardiovascular system: rarely – chest pain.


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